Jacksonville is located just north of the California and Oregon border just off of I-5. Jacksonville is a 5 hour drive north from San Francisco and Sacramento and an 11 hour drive north from Los Angeles.
Portland is located 4 1/2 hours north on I-5 and Seattle is 7 hours north of Jacksonville.
From the South: Take I-5 over the CA/OR border and exit at Exit 24 and turn left. Turn right on Hwy 99 and proceed to South Stage Road. Turn left on South Stage and follow the signs to Jacksonville.
From the North: exit OR-238 and proceed to Hanley Road and turn left to Jacksonville.
You may also reach Jacksonville from the Northern California Coast by taking US-199 to Grants Pass where it merges with 1-5 South, then exit in Medford on OR-238 and follow the signs to Jacksonville.